Age-Related Macular Degeneration: A Complementopathy?
نویسندگان
چکیده
منابع مشابه
Age-related macular degeneration: a complementopathy?
Age-related macular degeneration (AMD) is a progressive eye disease affecting many elderly individuals. It has a multifactorial pathogenesis and is associated with numerous environmental (e.g. smoking, light and nutrition) and genetic risk factors. A breakthrough in the mechanisms causing AMD is emerging; the involvement of the alternative pathway of the complement system appears to play a pivo...
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age-related macular degeneration (armd) is a major cause of central blindness among working aged adults across the world. systematic research planning on any subject, including armd is in need of solid data regarding previous efforts in this field and to identify the gaps in the research. this study aimed to elucidate the most important trends, directions, and gap in this subject. the data extr...
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amd بیماری تحلیل شبکیه است که عامل اصلی کوری در افراد بالای 55 سال در جهان غرب به شمار می-رود. در اثر این بیماری، لیپوپروتئین ها در شبکیه تجمع پیدا کرده و رگ زایی القاء می شود. ثابت شده است که عوامل ژنوتوکسیک محیطی مثل سیگار کشیدن، رژیم غذایی و نور در افراد پیر با زمینه ی ژنتیکی مستعد در بروز بیماری دخیل می باشند. بنابراین ما یک مطالعه ی مـورد- شاهـدی را ترتیب دادیم که شـامل 112 فرد مبتلا به am...
the genetics of age-related macular degeneration
age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...
متن کاملMacular pigment and age related macular degeneration.
The present concepts of the pathogenesis of AMD include cumulative light damage by oxidative processes in the macular photoreceptors as environmental co-factor for the development of AMD. The direct causative connection of this hypothesis has still to be established but wide circumstantial evidence from epidemiological and basic scientific investigations are strongly supportive. Macular pigment...
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ژورنال
عنوان ژورنال: Ophthalmic Research
سال: 2015
ISSN: 0030-3747,1423-0259
DOI: 10.1159/000432401